MOTS-C 40mg

MOTS-c Peptide

MOTS-c (Mitochondrial Open reading frame of the 12S rRNA-c) is a 16–amino acid peptide encoded by the mitochondrial genome (within the 12S rRNA region). It is classified among mitochondrial‑derived peptides (MDPs) that may act as retrograde signals between mitochondria and nucleus, modulating metabolism and stress responses. Under metabolic stress (e.g. glucose restriction, oxidative stress), MOTS‑c has been shown to translocate from mitochondria into the nucleus, where it can influence nuclear gene expression and metabolic pathways.

Overview & Mechanism…